Winston-Salem Tobacco Historic District, Industrial heritage district in Winston-Salem, North Carolina.

The Winston-Salem Tobacco Historic District is a 31-acre industrial section containing 16 contributing buildings and 16 structures that developed between 1890 and 1959. The area displays a mix of massive tobacco warehouses and varied commercial buildings lined along several streets through the city center.

The district's buildings date from about 1890 to 1959 and relate to the tobacco industry, specifically the R. J. Reynolds Tobacco Company. It also holds a once-thriving African American section and a wholesale commercial district that catered to Reynolds workers. It was listed on the National Register of Historic Places in 2009.

The district served as the economic heart for tobacco workers across generations and housed a thriving African American business quarter alongside wholesale trading zones. The spaces today show how daily life was interwoven with the tobacco industry.

The area is best explored on foot by following the boundaries along Chestnut Street, Fifth and Seventh Streets, Linden Street, and Fourth and Fogle Streets. Many buildings remain in private hands, but the street-level views offer good perspectives of the facades and overall layout.

The S. J. Nissen Building and the Piedmont Leaf Tobacco Company are both inside the district but listed separately on the National Register, so they carry their own reference numbers. The district itself was listed in 2009, covering 16 contributing buildings and 16 structures built from about 1890 to 1959.