South Wedge Historic District, Historic district in southeast Rochester, United States.

The South Wedge Historic District is a residential area in southeast Rochester, New York, with 434 contributing buildings, mostly two-story detached houses built between the 1840s and 1920s. The architecture is primarily vernacular, with a few high-style Italianate and Queen Anne residences, plus separately listed Saint Andrew's Episcopal Church and Nazareth House.

The area developed as a popular residential neighborhood during Rochester's industrial growth, attracting workers and merchants. It was added to the National Register of Historic Places in 2013, recognizing its importance to American architectural history.

The neighborhood displays homes from different periods that show how people's building tastes changed over time. You notice these differences in the facades and details when walking through the streets.

The district lies southeast of downtown Rochester, with contributing buildings on the streets around the intersection of South Avenue and Gregory Street. Saint Andrew's Episcopal Church and Nazareth House are separately listed, so look for them by name rather than on the district's own inventory. Most of the housing is private, so view the facades from the public sidewalk.

The district holds 434 contributing buildings, and among them Saint Andrew's Episcopal Church and Nazareth House are listed separately on the National Register, apart from the district's own 2013 listing. St. Boniface Church, the former School 13, former School 28 and former Engine Company No. 8 are the other named buildings in the nomination.