Mariano Moreno bus station, Main bus terminal in Rosario, Argentina

The Terminal de Ómnibus Mariano Moreno occupies a 1929 railway station building designed by architects Enrique Chanourdie and Micheletti, covering about three blocks bounded by Cafferata, Santa Fe, Castellanos and Córdoba streets, 3 km west of downtown Rosario. It has 50 platforms, 50 ticket offices, a 2,300 m² food court and waiting rooms.

The building began in 1929 as a railway station for Santa Fe Province before being converted into a bus terminal in 1950. This transformation allowed the city to adapt its transportation system to the growing importance of bus travel.

The station's name changed three times: inaugurated in December 1950 as "Coronel Perón", it became "Estación de Ómnibus Rosario" after the 1955 Revolución Libertadora removed Perón's name, and in 1957 it was renamed Mariano Moreno, honoring a ideologue of the May Revolution.

The terminal sits about 3 km west of the microcentro, on a site bounded by Cafferata, Santa Fe, Castellanos and Córdoba streets. Buses leave quickly via Bv. Avellaneda, Av. Alberdi and Bv. Rondeau toward the Rosario-Santa Fe and Rosario-Victoria routes, and via Av. Francia and Bv. Oroño toward the Buenos Aires highway. Entrances were added on Castellanos and Santa Fe during the 2011-2012 works.

The terminal was thoroughly renovated in 2014 and gained a large food court featuring multiple restaurants and cafes. This addition gives travelers more places to eat and rest during layovers between connections.