Iglesia de San Sebastian, Catholic church in La Paz, Bolivia.

The Iglesia de San Sebastián stands at the corner of Bozo Street and Alonso de Mendoza Square in La Paz. It is a Catholic church with stone walls, a dome and a transept; the dome and part of the transept collapsed in March 2006 and were restored by March 2016, when the floor was replaced with comanche stone while keeping the original architectural harmony.

Founded on 20 October 1548 by corregidor Alonso de Mendoza and cacique Kirkinchu, the first chapel was dedicated by vote of the vecinos to Saint Peter and later renamed San Sebastián. The foundational stone was laid under its protection on 26 November 1548. Destroyed in 1781 during the indigenous siege, it was rebuilt the following year; after the 1885 fire left it in ruins, restoration completed in March 2016 replaced the floor with comanche stone while keeping the original architectural harmony.

Parishioners hold that couples married in San Sebastián stay together for life and that children baptized there grow up as good sons and daughters. The parish serves the faithful of the whole city, with preference for the popular sectors of El Alto, and hosts the San Judas Tadeo youth and altar-server group, the Legion of Mary and neocatechumenal communities.

The church sits at a recognizable street corner near a central plaza in La Paz where it is easy to locate. Visitors should know that the building is regularly maintained and its interior is arranged in a traditional manner.

The image of Nuestra Señora del Pilar de Zaragoza was given to the city by Emperor Charles V in 1552 to be venerated as patroness of the Corregimiento. It stands on the church altar and is kept today under the advocation of Nuestra Señora de la Asunta.