Largo de Santana, Historic square in Rio Vermelho, Salvador, Brazil.

Largo de Santana is a historic square in Rio Vermelho with a church and significant buildings that shape its character. The square connects different streets and creates a space that draws both visitors and residents together.

Rio Vermelho began as a sesmaria granted by Tomé de Souza, with corrals and fishing structures. Settlement grew after the Dutch fleet of 26 ships and 3,400 men invaded Salvador in May 1624; Bishop D. Marcos Teixeira organized resistance from Morro do Conselho. The core of Santana stabilized between the Paciência and Mariquita settlements during the Second Reign, and the square was listed by IPAC in 2006.

The name Santana refers to Saint Anne, the neighbourhood's patron saint. The square is the centre of Rio Vermelho's bohemian life, lined with bars, hotels and old mansions, and it was listed as historic heritage by IPAC in 2006.

Largo de Santana sits in Rio Vermelho, a short walk from the neighborhood's beachfront. The square and its surrounding streets hold bars, hotels and old mansions converted into restaurants and shops. Nightlife concentrates after dark, when the bars stay open late, so daytime visits suit those who want to see the buildings without crowds.

The name Santana refers to Saint Anne, and the square's consolidation between the Paciência and Mariquita settlements dates from the Second Reign. In 2006 it was listed as historic heritage by IPAC, the Bahia state institute for artistic and cultural heritage.