Ditsong National Museum of Natural History, Natural history museum in Pretoria, South Africa.

The Ditsong National Museum of Natural History occupies a building on Paul Kruger Street, between Visagie and Minnaar Streets, opposite the Pretoria City Hall. Its halls hold Plio-Pleistocene fossils from Sterkfontein, Swartkrans and Kromdraai, late Permian therapsids from the Karoo, and collections of mammals, birds, reptiles and invertebrates. The most complete skull of Australopithecus africanus, Mrs Ples, is on display.

The institution was founded in 1892 as the Staatsmuseum and played an important role in documenting South African nature. In 2010 it received its current name and became part of a nationwide museum organization.

The collection preserves South African natural heritage and displays fossils that show how early humans lived in this region. The exhibits tell the story of the natural world as people here have experienced it throughout history.

The museum stands on Paul Kruger Street between Visagie and Minnaar Streets, facing the Pretoria City Hall. It opens from 8:00 to 16:00 seven days a week, except on certain public holidays. The entrance is at street level, and the galleries are arranged over more than one floor.

The museum holds the most complete skull of an Australopithecus africanus, known as Mrs Ples, found at Sterkfontein in the Cradle of Humankind World Heritage Site. Its Plio-Pleistocene hominid fossils from Sterkfontein, Swartkrans and Kromdraai are a draw visitors often overlook beside the mounted mammals.