Prince Regent National Park, Nature reserve in Kimberley region, Western Australia.

Prince Regent National Park covers 5,764 square kilometres of the Kimberley, from a sandstone plateau around 500 metres high in the south down to about 100 metres near Saint George Basin, a tidal harbour reached through a narrow strait. The north holds volcanic formations, and the park rises to 850 metres. Its features include King's Cascade, Mount Trafalgar, Python Cliffs, Pitta Gorge and the Prince Regent River.

The area became protected in 1964 and received UNESCO Biosphere Reserve status in 1978. This recognition was based on its ecological importance to Western Australia.

The park lies mainly in Wunambal land, while the Worrorra are the traditional owners of the country around the Prince Regent River. In 1998 the Wanjina Wunggurr native title claim was lodged, and on 23 May 2011 the Uunguu determination granted the Wunambal people native title over 25,909 km², including the park's inland parts and the waters of Admiralty Gulf and York Sound down to Coronation Island.

Entry requires a permit and is only possible by boat or aircraft since there are no roads to the park. Visitors should expect limited facilities and be prepared for remote conditions.

Careening Bay on Coronation Island holds the Mermaid Tree, a boab whose trunk was carved by the carpenter of HMS Mermaid when Philip Parker King's ship was beached for repairs. The inscription survives in the park's remote northwest.