Gamble House, Arts and Crafts residential masterwork in Pasadena, United States.

Gamble House is a two-story Arts and Crafts home in Pasadena, its walls clad in dark brown wood shingles under a low-pitched roof with wide overhanging eaves. A brick chimney rises at the roof center, and a covered pergola with square posts extends from the right side of the facade. A rectangular sign reading "GAMBLE" is mounted beside the red-framed glass entrance doors.

David and Mary Gamble, of Cincinnati's Procter & Gamble family, hired Greene and Greene in May 1907 to design a winter home; it was built in 1908–1909. The couple wintered here until their deaths in 1923 and 1929, and Mary's sister Julia lived on until 1943. In 1966 the family transferred the house to Pasadena in agreement with the USC School of Architecture; it became a National Historic Landmark in 1977.

The house takes its name from David B. Gamble, son of Procter & Gamble co-founder James Gamble, and his wife Mary, who wintered here from Cincinnati. The Gamble family gave the house to the city of Pasadena and USC in 1966. The family crest, a crane with a trailing rose, appears in wood, glass and stone throughout the rooms.

Advance reservations for interior tours are required because visitor numbers are limited. Tours take place Tuesday through Sunday and last about an hour.

The architects designed most of the furniture specifically for these rooms, including tables and chairs with the same woodwork as the building. Even light switches and door handles were custom-made as part of the overall concept.