Little Picacho Wilderness, Protected wilderness area in Imperial County, United States.

Little Picacho Wilderness is a protected area in the Chocolate Mountains featuring rocky spires, steep ridges, and sandy washes across multiple tens of thousands of acres. The terrain rises and falls significantly, moving from low desert basins to higher summit areas.

The Little Picacho Wilderness covers 38,214 acres in a southeast extension of the Chocolate Mountains beside the Colorado River, in southeastern California. It is managed by the Bureau of Land Management and is one of several federally protected areas between Blythe, California, and Yuma, Arizona, in the Lower Colorado River Valley. It is separate from the Picacho Peak Wilderness to the northeast.

The area takes its name from the Picacho wild horses, a herd that roams the northwestern 5,000 acres of the wilderness. The same land is habitat for wild burros, desert tortoises, spotted bats and desert bighorn sheep, and it lies in the Lower Colorado River Valley between Yuma, Arizona and Blythe, California.

The wilderness lies north of Yuma, Arizona and south of Blythe, California, reached via unpaved desert roads; carry water, navigation tools and emergency supplies, as services and help are distant. The 38,214-acre area has no facilities, and the Picacho wild horse herd roams the northwestern 5,000 acres.

The Picacho wild horse roams only the northwestern 5,000 acres of the wilderness, a herd that takes its name from these hills. The area also gives habitat to wild burro, desert tortoise, spotted bat and desert bighorn sheep, and it is not the same as Picacho Peak Wilderness to the northeast.