Iglesia de Santa Bárbara, Santa Fe de Antioquia, Colonial church in Santa Fe de Antioquia, Colombia.

Iglesia de Santa Bárbara is a Baroque church with three naves supported by square pillars and semicircular arches that create a rhythmic interior space. The rectangular layout organizes the worship area with a clear hierarchy of architectural elements that guide visitors from entrance to altar.

The present church replaces an earlier straw-roofed Santa Bárbara built around 1668 by Captain Mateo de Castrillón, governor of the province. After King Philip V granted the founding charter for a Jesuit college in 1722, the parish priest donated the old church and its belongings to the Jesuits six years later, in 1728. The Jesuits began a larger temple in 1726, were expelled in 1767, and Juan Pablo Pérez de Rubias finished it in 1795.

The poet Julio Vives Guerra called it "La Abuela de las iglesias de la Provincia de Antioquia". The main altar, carved and gilded wood from the mid-18th century, holds the statue of Santa Bárbara in its central niche, flanked by San Fabián and San Sebastián. The tabernacle, an anonymous 18th-century hexagonal wooden temple, has a silver-lined expositorio and a central panel with a heart, the mystical lamb, vine and wheat.

The church sits two blocks from the main plaza, making it easy to find while exploring the city center on foot. Visitors can enter during open hours to view the interior architecture and artworks at their own pace.

The main facade lost its plaster coating, leaving stone and brick exposed, a change that conservation specialists consider harmful to the building. The interior also underwent reforms that altered its original appearance. The poet Julio Vives Guerra called the church "La Abuela de las iglesias de la Provincia de Antioquia".