Pemberton's Headquarters, Greek Revival mansion in Vicksburg, United States.

Pemberton's Headquarters is a large L-shaped house at 1018 Crawford Street, with a brick front section and a rear wood-frame addition. The front was built in stages: an 1836 main hall with flanking parlors, enlarged in brick around 1850, with rear additions around 1900. A retaining wall and steep terraced landscaping separate it from the street, and a concrete stair climbs to the entrance.

Built probably by William Bobb and sold in 1836 to planter John Willis, the house was enlarged in brick around 1850. Confederate General John C. Pemberton used it as his headquarters during the 47-day Siege of Vicksburg and surrendered the city there on July 3, 1863. The Willises sold it in 1886; Mary Cowan bought it in 1890, and the Sisters of Mercy ran it as St. Anthony's Hall until 1973.

The house is named for Confederate General John C. Pemberton, who used it as his command post during the 47-day siege. The National Park Service now runs it to interpret the Confederate leadership's experience and the conditions inside the besieged city.

The house stands on the south side of Crawford Street, just west of Adams Street, on the eastern edge of downtown Vicksburg. It sits above street level behind a retaining wall and steep terracing, reached by a concrete stair through the landscaping. The National Park Service owns it and opens it as part of Vicksburg National Military Park.

After the war, the Sisters of Mercy took over the building and operated it as St. Anthony's Hall for educational purposes. This phase as a school run by the religious community lasted more than 50 years and gave the building a completely different purpose.