Hampton-Preston House, Historic house museum in Columbia, United States.

The Hampton-Preston House is a post-Colonial Classical Revival mansion at 1615 Blanding Street, with a broad front veranda on Doric columns and a fanlight above. Inside, a circular stairway has mahogany rails and a crystal chandelier hangs in the hall. Its gardens once covered a city block but were cleared and became a parking lot.

Ainsley Hall, a wealthy Columbia merchant, built the house in 1818. Former War of 1812 general Wade Hampton I, a cotton planter, bought it a few years later; his son Wade Hampton II and grandson Wade Hampton III also lived there at times. After Hampton I's death, ownership passed to his daughter Caroline and her husband, State Senator John S. Preston, who doubled the house's size. During the Civil War's latter part, Union Maj. Gen. John A. Logan used it as headquarters during Columbia's occupation. The South Carolina Presbyterian Institute for Young Ladies acquired it in 1890.

The house displays classical architectural elements that reflect the wealth and artistic taste of South Carolina's leading families in the 1800s. Visitors can observe how this elite designed and furnished their living spaces.

The Hampton–Preston House stands at 1615 Blanding Street in Columbia, within the Columbia Historic District II. The gardens that once covered a city block are gone, replaced by a parking lot, so visitors should not expect grounds to walk. The house is operated as a museum by the Historic Columbia Foundation, which reopened it to the public in 1970.

The white marble mantel in one room was carved by Hiram Powers, an American sculptor who later settled in Florence. The gardens that once covered a full city block and were known across South Carolina were plowed under and felled, and the site eventually became a parking lot.