Burr Mansion, Historic house in Cow Hollow, San Francisco, US.

Burr Mansion is a three-story wooden house with a brick foundation at 1772 Vallejo Street in Cow Hollow. Designed by Edmund M. Wharf, it combines Italianate styling with a French Second Empire mansard roof. The white clapboard facade has stacked bay windows, arched dormers, and a low wrought-iron fence.

Ephraim Willard Burr, the 8th mayor of San Francisco and a banker, commissioned the house as a wedding gift for his son Edmond Coffin Burr and his fiancée Anna Barnard. Architect Edmund M. Wharf designed it, and it was built between 1875 and 1878 on a 12,535 square foot lot. It has been a San Francisco Designated Landmark since May 3, 1970, and joined the National Register of Historic Places on June 8, 2015.

The house was commissioned by Ephraim Willard Burr, the eighth mayor of San Francisco and a banker, as a wedding gift for his son Edmond Coffin Burr and Anna Barnard. The garden cottage on the grounds was used exclusively by Burr's daughter Alice, born in 1883. From 1970 or 1971 the building housed the Humanistic Psychology Institute, later Saybrook University.

The house stands at 1772 Vallejo Street in Cow Hollow, and its facade, bays and iron fence are visible from the public sidewalk. It remains a private residence, so visits are limited to the exterior; the garden cottage and grounds are not open to the public.

The estate contains one of San Francisco's largest residential parcels and includes a separate cottage with its own garden. This additional structure was originally designed for the owner's daughter.