De Vargas Street House, Historic adobe structure in Santa Fe, United States

The De Vargas Street House is a historic adobe building from early New Mexico, preserving original dirt floors, low ceilings, and thick adobe walls. Today it operates as both a craft shop and museum.

The building's construction date is unknown; most of it is believed to date from the Spanish colonial period after 1610. In 1902 archaeologist Edgar Lee Hewett examined the walls during repairs and found that about three-fourths were old Mexican adobe masonry contemporary with San Miguel Chapel, while three low sections of puddled adobe, nowhere more than 18 inches high, matched the pueblo walls of Kuapoge. Dendrochronology of the ceiling vigas later indicated wood cut between 1740 and 1767.

The house stands in El Barrio de Analco, a neighborhood founded by Tlaxcalan warriors who accompanied Spanish settlers in the early 1600s. The district still shapes Santa Fe's character today with its narrow streets and traditional adobe homes.

The house stands at 215 De Vargas Street, across the Santa Fe River from the Plaza in the Barrio de Analco, next to San Miguel Mission. It remained a residence until 1920 and is now a tourist site; the second story was rebuilt in the 1920s, so the interior is small.

Local legend holds that two witches once lived in the house and sold love potions; one beheaded a dissatisfied customer, and on the anniversary of his death his head is said to roll along the road. The story is repeated in Santa Fe lore rather than documented in any record.