Chief Mistawasis Bridge, Road bridge in Saskatoon, Canada.

Chief Mistawasis Bridge is a road crossing over the South Saskatchewan River with six traffic lanes and two paths for pedestrians and cyclists. It connects two major areas and serves as part of the city's modern traffic infrastructure.

Construction of the Chief Mistawasis Bridge was financed together with the replacement for the 1907 Traffic Bridge downtown, which had closed in 2010; that separate project opened to traffic on October 3, 2018. In July 2016 officials announced the new bridge would carry a name tied to Canada's Indigenous peoples, and on June 21, 2018 it was named for Mistawasis, head of the Prairie Tribe and a signatory of Treaty 6 in 1876. The bridge opened on October 2, 2018.

The bridge carries the name of a Cree leader, honoring the presence and history of Indigenous peoples in this region. The naming reflects how the city recognizes these communities and their role in the area's story.

The bridge links two parts of the city and significantly eases traffic flow in this area. The location is easily accessible by car, foot, or bike, with dedicated paths making crossing on foot or cycling quite convenient.

In March 2017, a berm built in the riverbed to channel water around the pier construction created a standing wave that drew urban surfers; officials warned that construction made the water near the bridge extra hazardous. The bridge deck stands 21.6 metres above the river, making it Saskatoon's second-highest bridge.