Greek Sophia Church, Kherson, Orthodox church in Kherson, Ukraine.

The Greek Sophia Church is an Orthodox church building in Kherson featuring multiple domes and ornamented exterior walls decorated with religious symbols and carved stonework. The interior contains an iconostasis and religious objects arranged according to Orthodox tradition, defining the sacred space.

Greek settlers from Chios, led by the brothers Dmitry, Afanasy and Stepan Gunaropulo, received permission from Ivan Hannibal, commander of the Kherson fortress, and built a small clay-walled church with a wooden frame in 1778; its altar was consecrated on 10 November 1778 by Archbishop Nikifor. A stone church replaced it over two years, completed in 1780, and it kept its original appearance and interior. Grigory Potemkin, Alexander Suvorov, Fyodor Ushakov and Osip de Ribas prayed here. Russian shelling damaged the walls and roof on 11 April 2023, and another strike on 14 December 2023 hit the altar area and ceiling.

Locals have called it simply the Greek Church for three centuries, though its official name is the Nativity of the Theotokos (Greek-Sophia) Church. Services were held in Greek and continued even during World War II. The church keeps a walnut five-tier iconostasis with 104 icons and a Gospel printed in 1719.

The church stands at 11 Bohorodytska Street, in the former Greek suburb; the entrance is on the west side, through the three-tiered bell tower. Services have been held in Greek and never stopped, even during World War II. The walls and roof were damaged by shelling on 11 April and 14 December 2023, so parts of the building may be closed.

The church is a basilica, not a cross-domed building like most Orthodox churches in Kherson: two rows of columns divide the interior into three naves, ending in low apses to the east. On the third tier of the bell tower stand four life-size carved wooden statues of the evangelists Matthew, Mark, Luke and John.