Cayenne Cathedral, Roman Catholic cathedral in central Cayenne, French Guiana.

Cayenne Cathedral is a stone-and-brick church with a bell tower whose oak frame and copper roof were restored in 1998, after 19 years of silence from its bells. The building was enlarged eastward by 13 m between 1952 and 1954, when the ceiling, stained glass and gallery floors were replaced. Its interior holds the main altar, pulpit and confessional transferred in 1876 from the prison chapel of Ilet la Mère.

The first church, Saint-Nicolas, was begun in 1825 and finished in 1833 on the site of today's Place Léopold-Héder. A stone-and-brick replacement was built from 1925 to 1933, and on 9 November 1934 Bishop Gourtay consecrated it as cathedral when the apostolic prefecture became a vicariate. The building was enlarged eastward by 13 metres between 1952 and 1954.

This cathedral serves as the main religious hub of Cayenne, where locals gather for worship and community celebrations throughout the year. It shapes the identity of the city center and remains a focal point for residents.

The cathedral sits in Cayenne's central area with straightforward access and clear orientation. Visiting outside service hours allows you to explore the interior and furnishings at a leisurely pace without interruption.

The master altar, pulpit and confessional now in the cathedral came from the chapel of the Ilet la Mère penal colony and were transferred here in 1876. The island lies off the coast near Cayenne, and the pieces are among the furnishings a visitor can still see inside.