Monastero di Santa Chiara, Renaissance monastery in Urbino, Italy.

Monastero di Santa Chiara is a Renaissance monastery in Urbino, central Italy, now used as an educational institution. The building features arched windows, symmetrical courtyards, and the balanced proportions typical of that architectural period.

A first building rose on the site around 1420 as a Conservatory for widowed women; in 1456 Pope Callixtus III granted it the Rule of the Observance of Saint Clare through Duke Federico III da Montefeltro. In 1482 his daughter Elisabetta retired here after the death of her husband Roberto Malatesta, took vows and funded a rebuilding designed by Francesco di Giorgio Martini, left unfinished. From 1538 the church became the ducal mausoleum of the Della Rovere, and around 1620 Francesco Maria II had it reduced to a central plan.

The Clarisse nuns left in 1863, when church property was confiscated after Italian unification; over a hundred works were taken from the monastery, including the celebrated panel Città ideale, which formed the first nucleus of the Galleria nazionale delle Marche. Since the 1970s the building has housed the ISIA, the higher institute for artistic industries.

Since the building now operates as a school, access to most areas requires prior arrangement and is not open to casual visitors at any time. Going outside of term time may improve the chances of seeing more of the building.

During the four-year restoration completed on 22 September 2011, the remains of the Montefeltro and Della Rovere dukes were moved from the crypt into a janitorial closet at the ISIA institute. The church had become the ducal mausoleum from 1538, starting with Duke Francesco Maria I Della Rovere and Eleonora Gonzaga.