Palazzo Pignatelli di Monteleone, Naples, 16th-century palace in Piazza del Gesù Nuovo, Naples, Italy.

Palazzo Pignatelli di Monteleone is a five-storey palace on Calata Trinità Maggiore, its facade facing Piazza del Gesù Nuovo. The 1718 portal by Ferdinando Sanfelice is framed in white marble with pointed diamond rustication, flanked by composite columns whose capitals are carved as anthropomorphic masks. Inside, the entrance hall keeps a barrel vault and the staircase cross vaults with ribs; the rest was divided into flats.

The palace was built from 1561 for Girolama Colonna, wife of Camillo Pignatelli, third duke of Monteleone, on land ceded by the monastery of Santa Chiara; Giovanni Vincenzo Della Monica designed it. Duke Nicola Pignatelli had it enlarged in 1718 under Ferdinando Sanfelice, who planned an octagonal courtyard that was never built. In 1788 the building was split into Palazzo grande and Palazzo piccolo, and the Grande passed between 1823 and 1832 to the French banker René Hilaire Degas.

Neapolitans call the palace "palazzo d' 'o Gas", a deformation of the surname of the Degas family, who lived here in the 19th century. The French banker René Hilaire Degas, grandfather of the painter Edgar, bought the Palazzo Grande between 1823 and 1832 after fleeing the French Revolution. Around 1875 Edgar and his cousin Lucie inherited part of it.

The palace stands at Calata Trinità Maggiore 2, where its facade meets Piazza del Gesù Nuovo, in the historic centre of Naples. The building is divided into private flats and guest accommodation, so the entrance and courtyard are not open to visitors; the marble portal and its mask capitals are seen from the street.

A marble plaque on the facade marks the frequent visits of painter Edgar Degas, whose grandfather Rene Hilaire Degas owned the property. This connection to the renowned artist gives the palace a special place in Naples's cultural past.