Riserva naturale orientata Pantalica, Valle dell'Anapo e Torrente Cava Grande, Nature reserve in the Iblei Mountains, Sicily, Italy

The Riserva naturale orientata Pantalica, Valle dell'Anapo e Torrente Cava Grande is a protected area across Buscemi, Cassaro, Ferla, Palazzolo Acreide and Sortino, established in 1997. The Anapo, rising on Monte Lauro in the Iblei Mountains, and the Calcinara cut V-shaped canyons; on the overhanging walls of the Pantalica canyon around 5,000 tombs are cut into the rock. The reserve also holds the Grotta dei Pipistrelli and Grotta Trovata, two karst caves, and the Giarranauti wood near Ferla.

The reserve was created by decree D.A. 482/44 of 25 July 1997, covering land in Buscemi, Cassaro, Ferla, Palazzolo Acreide and Sortino, and managed by the regional department of state forest companies. Its slopes above the Anapo and Calcinara canyons hold about 5,000 tombs cut into the rock faces, the largest necropolis in Europe. In the early 1900s a railway crossed the Anapo valley with a stop called Necropoli di Pantalica; it closed in the 1950s.

The reserve's name joins three areas: the Pantalica valley with its rock-cut tombs, the Anapo valley, and the Cava Grande stream. The Anapo rises on Monte Lauro in the Iblei Mountains and reaches the sea at the port of Siracusa. A railway built in the early 1900s crossed the Anapo valley and had a stop called Necropoli di Pantalica.

Two cycling and walking routes have been set up in the reserve. The one in the Giarranauti forest, near Ferla, climbs for about 5 km through woodland. The second follows the old Siracusa–Vizzini railway bed through the Anapo valley and requires authorisation from the forestry service.

The Anapo valley carried the Siracusa–Vizzini railway in the early 20th century, with a stop named after the Pantalica necropolis. The line closed in the 1950s, but its tunnels and early-1900s railway buildings can still be walked, and the old trackbed now forms a cycling and walking route used with forestry permission.