Tupitsiny House in Perm, Regional cultural heritage site in Perm, Russia.

The Tupitsiny House is a three-storey stone mansion at the corner of Petropavlovskaya Street and 25th October Street in Perm, built in 1888 to a design by architect A. B. Turchevich. It has two small towers, and a later annex added a third tower. The building now houses the local FSB directorate.

The house was built in 1888 for the Tupitsiny family, wealthy industrialists who gained significant economic influence in the Perm region. Its construction occurred during a period of rapid industrial growth in the city.

The Tupitsyn brothers, pioneers of phosphorus production in the Russian Empire, rented out this mansion in the city centre. For about a year it was home to Vasily Shishonko, a physician, teacher and local historian married to their sister Vera Evgrafovna. From 1920 the House of Unions gathered trade unions here, including Rabis, the arts workers' union, and a radio hub beside them relayed broadcasts from other cities to Perm.

The building stands at the corner of Petropavlovskaya Street and 25th October Street in central Perm. It now houses the FSB Directorate for Perm Krai, so the interior is not open to visitors; the 1888 facade with its two towers can be viewed from the street.

The building served as both a home and workspace, with specific rooms designed where the family conducted business and met with their associates. This blending of private life and business under one roof was common among successful entrepreneurs of that era.