Fayette National Bank Building, Historic skyscraper from 1914 in downtown Lexington, United States.

The Fayette National Bank Building is a 15-story Beaux-Arts high-rise at West Main Street in downtown Lexington, Kentucky. McKim, Mead & White designed it and the George A. Fuller Company built it in 1913–1914. It is listed on the National Register of Historic Places and now houses the 21c Museum Hotel.

McKim, Mead & White designed the building, and the George A. Fuller Company constructed it from 1913 to 1914. It was added to the National Register of Historic Places on February 27, 1980. In 2016 it became a 21c Museum Hotel, and in 2019 it joined Historic Hotels of America.

The building's classical details like Ionic columns, marble surfaces, and ornamental plasterwork still shape how visitors experience the interior spaces today. These elements connect the structure to early 20th-century craftsmanship traditions that remain visible throughout.

The building now operates as the 21c Museum Hotel, featuring 88 rooms, a restaurant, and exhibition spaces following extensive renovation work completed in 2016. Visitors can experience the historic architecture through lodging or explore the galleries and artistic offerings throughout the property.

The building's 2016 conversion into a 21c Museum Hotel cost more than $43 million and produced 88 rooms, a restaurant and museum space. In 2019 it was inducted into Historic Hotels of America, the National Trust for Historic Preservation's official program.