Plaza Egaña, Central plaza in Ñuñoa, Chile.

Plaza Egaña is a plaza and neighbourhood on the boundary between Ñuñoa and La Reina, crossed by Avenida Américo Vespucio. The plaza itself lies on the northwestern corner, on the Ñuñoa side, along Avenida Irarrázaval, where banks and shops stand among high-rise buildings. Mall Plaza Egaña occupies the northeastern corner on Avenida Ossa, and the Eco Egaña project, with four towers, is under construction on the southwestern side.

The plots forming today's square were bought in 1892 by Osvaldo Ramírez within the Población Nueva de los Guindos, carved from the Hijuela Tobalaba between 1892 and 1895. In 1894 the Sociedad del Ferrocarril de Sangre de Ñuñoa acquired them; they passed to electric tramway firms and in 1899 to the Chilean Electric Tramway and Light Company, serving for decades as a station of the Ferrocarril Eléctrico de Ñuñoa. The name honours Mariano Egaña, drafter of the 1833 Constitution and owner of the Fundo de Peñalolén.

The name honours Mariano Egaña, drafter of the 1833 Constitution and owner of the Fundo de Peñalolén. From the first half of the 20th century the area attracted Palestinian immigrant families such as the Sabaj, Nallar and Meruane; Juan Sabaj Street recalls the immigrant who arrived in Chile in 1907. In the late 1970s and 1980s the plaza was a meeting and recreation spot known for its schoperías and the Manuel Plaza gymnasium, where Santiago's first rock fans gathered.

Plaza Egaña metro station has combined Line 4 with Line 3 since 2019, when the Line 3 extension opened; Line 4 had served the square since 2005. The station sits at the Ñuñoa–La Reina boundary on Américo Vespucio, so transfers between the two lines are made underground. The square itself lies on the northwestern, Ñuñoa side, along Irarrázaval Avenue.

The plaza hosts a major retail development with Mall Plaza Egaña, combining shopping and leisure activities in a single location. Additionally, the Eco Egaña project with its four residential towers marks a contemporary reshaping of the southwestern corner and signals the transformation of this historic site.