John Monash Science School, Specialist science secondary school in Clayton, Australia.

John Monash Science School is a government-funded specialist secondary school for science, located on the Clayton campus of Monash University in Melbourne's south-east. It has purpose-built laboratories and research spaces that sit directly within the university grounds.

The school opened in 2009 as the first specialist science secondary school in the state of Victoria, starting with a single Year 10 intake. Over the following years it grew gradually until all year levels were filled.

Students belong to four houses named after Australian scientists: Flannery (green, griffin), Blackburn (purple, phoenix), Wood (silver, wolf) and Doherty (blue, dragon). The names honour Tim Flannery, Elizabeth Blackburn, Fiona Wood and Peter Doherty, and each house has its own colour and mascot worn and displayed at school events.

The school is on the Clayton campus of Monash University in Melbourne's south-east. Entry to Year 10 is competitive: applicants sit an EduTest entrance examination assessing scientific reasoning and mathematical aptitude, about 600 are interviewed, and around 200 places are offered. A limited number of Year 11 places, typically 25 to 30, are also offered each year.

Since 2013, the NBN Virtual School of Emerging Sciences has offered online courses in astrophysics and nanoscience, taught jointly by school staff and Monash University scientists. These courses reach students anywhere in Australia, including those in remote areas far from any university campus.