Jenner House, Heritage residence in New South Wales, Australia.

Jenner House is a three-level marine villa at 2 Macleay Street, Potts Point, with a partial basement and a detached 1920s garage in the south-western corner. Edmund Blacket designed the 1871 two-storey house and service wing; Thomas Rowe added the third floor in 1877. Internal detailing is by Blacket and his then employee J. Horbury Hunt.

The site came from the 1866 subdivision of Alexander Macleay's Elizabeth Bay estate. Retailer Lebbeus Hordern took a 99-year lease and commissioned Edmund Blacket to design a two-storey house, Stramshall, built in 1871. Thomas Rowe added a third storey in 1877. From 1915 it served as Jenner Private Hospital, where Sir Matthew Harris died in 1917 and James Sharpe in 1935. The Royal Australian Navy took over in 1952, and it was listed on the NSW State Heritage Register in 2001.

Jenner House carries a sequence of names from its past: Stramshall when built in 1871, then Kurragheen and Lugano, before becoming the Jenner Private Hospital in 1915. The name Jenner comes from that hospital period, when the building served patients rather than a household.

Jenner House is a private residence at 2 Macleay Street, Potts Point, and is not open to the public; it can be seen from the street. The three-storey facade, the single-storey 1920s garage in the south-western corner and the remnant outbuilding walls to the north-west are the visible elements. The site stands on land subdivided from Alexander Macleay's Elizabeth Bay estate in 1866.

The 1920s garage in the south-western corner survives from the building's years as Jenner Private Hospital, when the site was altered for medical use. Much of the foreshore garden was destroyed after 1940, when the Commonwealth resumed the property for the Captain Cook Graving Dock.