Rancho Guajome Adobe, Historic adobe hacienda in Vista, United States.

Rancho Guajome Adobe is a 20-room Spanish Colonial hacienda built in 1852–53 on North Santa Fe Avenue in Vista, with two courtyards and an arcaded veranda. The arches were added in the 1920s; the surrounding grounds hold stables, a blacksmith shop, a chapel and a carriage house.

Abel Stearns gave Rancho Guajome to Ysidora Bandini as a wedding gift when she married Cave Johnson Couts in 1851. The adobe was built in 1852–53 with profits from the 1850s cattle boom, when ranchos supplied Gold Rush miners with meat and leather. Couts, appointed sub-agent for the Luiseño in 1853, used their labor to improve this and nearby ranches. San Diego County bought the property through condemnation finalized in 1973 and completed a rehabilitation in 1996.

Rancho Guajome is linked with Helen Hunt Jackson's 1884 novel Ramona, alongside Casa de Estudillo and Rancho Camulos. Cave Johnson Couts, who married Ysidora Bandini in 1851, was appointed sub-agent for the Luiseño people in 1853 and used their labor to improve this rancho and his nearby properties. The house later served as a historic house museum.

The adobe stands on the south side of North Santa Fe Avenue in northwestern Vista, just east of Guajome County Park across the road. The county park around it covers 112 acres, and both guided and self-guided tours are offered. The park facilities can be booked for special events.

The 112-acre county park around the adobe was assembled through condemnation proceedings finalized in 1973, when San Diego County paid just over $1,000,000 for the ranch. Earl "Sonny" Richardson, who had run the property, was the last family occupant. A rehabilitation begun in the 1970s was completed in 1996.