Downtown Santa Ana Historic Districts, Three historic districts in Downtown Santa Ana, California.

The Downtown Santa Ana Historic Districts cover 24.5 acres listed as one entry in the National Register of Historic Places since 1984. They span several sub-districts, including the Civic Center, Calle Cuatro (Fourth Street), the Artists Village and the East End. The districts are characterized by Art Deco buildings and two old movie houses, The West End and the Fox West Coast.

William Spurgeon founded Santa Ana in 1869 on 74.27 acres bought from Rancho Santiago de Santa Ana, a former Spanish land grant. In 1889 he and James McFadden formed Orange County, and Santa Ana became its seat because it had grown larger than neighbouring towns such as Orange. The Old Orange County Courthouse followed in 1901, and the historic districts were listed on the National Register in 1984.

Fourth Street, called Calle Cuatro, holds the Rankin Building at 117 W Fourth Street, a reminder of the department stores Rankin's, Montgomery Ward, J. C. Penney and Buffums that once lined it; trade moved to malls such as Honer Plaza and Santa Ana Fashion Square after 1958. The Artists Village, proposed in the mid-1980s and designated after the 1994 Grand Central Art Center plan, gathers galleries, studios and restaurants around Second Street and Broadway, including the Orange County Center for Contemporary Art.

Downtown is generally defined as the area between Ross Street to the west, Minter Street to the east, First Street to the south and Civic Center Drive to the north; neighborhood groups draw the eastern edge at Main Street. The Santa Ana Regional Transportation Center, the train and bus station, sits at the east end of the Lacy neighborhood along Santiago Avenue. The Civic Center anchors the west side, with City Hall, the public library and the county and federal courthouses grouped around Civic Center Plaza.

The districts were listed as one National Register entry in 1984, covering 24.5 acres (9.9 ha). Within them stand two early movie houses, The West End and the Fox West Coast, and the county's first theater, Walker's Theater, built in 1909 on Main and Second streets beside the old City Hall.