Historic Centre of Santa Cruz de Mompox, Colonial riverside heritage district in Santa Cruz de Mompox, Colombia.

The Historic Centre of Santa Cruz de Mompox is a colonial district on the Magdalena River in the department of Bolívar, Colombia. Its layout was shaped by churches and convents built by Augustinians, Dominicans, Franciscans and Jesuits. Among its monuments are the Church of San Francisco, the Church of Santa Bárbara, the Church of San Agustín, the Hospital of San Juan de Dios and the municipal house where Colombian independence was declared.

Founded in 1540, the town grew into a major trading post where Spanish merchants stored gold and operated a royal mint. The decline of river commerce in the 19th century helped preserve the colonial structures.

The town's churches and convents were built by Augustinians, Dominicans, Franciscans and Jesuits, and their layout shaped Mompox's street plan. Among the monuments are the Church of San Francisco, the Church of Santa Bárbara, the Church of San Agustín and the Church of the Immaculate Conception. The Casa Municipal is where Colombia's independence was declared.

The center is easily walkable on foot and fully accessible to visitors, with local restaurants and accommodation options available throughout. The best time to visit is during drier months to avoid flooding issues near the riverfront areas.

The Hospital de San Juan de Dios, listed among the town's monuments, is considered the oldest hospital in the Americas and remained in use until 2020. The Casa municipal is where Colombia's independence was declared.