Murano at Portofino, Residential skyscraper in South Beach, Miami Beach, US.

Murano at Portofino is a 37-floor residential tower on Biscayne Bay in Miami Beach's South of Fifth neighborhood. It opened in 2001, rises 402 ft (123 m), and holds eight floor plans from 1,000 to 3,400 sq ft. The building faces west toward the bay, Government Cut, and a partial view of the Atlantic.

The Related Group completed this residential complex in 2001 as a major new addition to the Miami Beach waterfront at the start of the new millennium. The project contributed to the large-scale transformation of the area.

The tower carries the names of two Italian places: Murano, the Venetian island known for glassmaking, and Portofino, the Ligurian harbour town. Developer Thomas Kramer's Portofino Group built it with the Related Group of Florida, and the name ties the building to the Italian-themed waterfront projects that reshaped South of Fifth around 2001.

The tower sits on a 4.5-acre site with over 600 linear feet of frontage on Biscayne Bay, next to the Miami Beach Marina in the South of Fifth (SOFI) neighborhood. Amenities listed for residents are a bay-front pool and spa, freshwater pools, tennis courts, a fitness center, a private beach club, media and multi-purpose rooms, 24-hour security and valet service. The building faces west, toward the bay and Government Cut.

Murano at Portofino is the eighth tallest skyscraper in Miami Beach, at 402 ft (123 m). Its 4.5-acre site gives it over 600 linear ft of frontage along Biscayne Bay, and the tower faces west, so units look toward Government Cut and partly toward the Atlantic.