Convento de los Dominicos, Santo Domingo, Catholic church in Santo Domingo, Dominican Republic.

The Convento de los Dominicos stands on Calle Padre Billini in the Ciudad Colonial of Santo Domingo. Its church was completed between 1531 and 1532 by the Carmonese architects Antón and Alonso Gutiérrez, and its portal mixes Gothic, Isabelline Gothic and Baroque elements. Inside, the Capilla de Nuestra Señora del Rosario, built in 1649, is covered by a barrel vault painted with the twelve zodiac signs around the sun and with Olympian gods representing the four seasons.

Construction began around 1510 when the Dominican Order arrived in Santo Domingo; friars occupied the convent by 1517, and the church was inaugurated in 1531–1532. In 1538 the convent became the Universidad de Santo Tomás de Aquino, the first university in the Americas. A 1545 hurricane and earthquakes in 1673 and 1684 damaged the building, which was restored in 1746 with Baroque facades. The Haitian government closed the church in 1825, and the Dominicans returned in 1954.

The Capilla de Nuestra Señora del Rosario, built in 1649, was rebuilt in 1746 by the Campuzano Polanco family, who replaced the nave's wooden roof with a barrel vault. The vault is painted with the twelve zodiac signs around the sun and with Olympian gods representing the four seasons, which is why it is also called the Capilla del Zodíaco. It is one of only three astrological vaults known today, alongside those of Salamanca and Río Seco.

The church and convent stand on Calle Padre Billini in the Ciudad Colonial, within the UNESCO World Heritage area, a short walk from the Alcázar de Colón and the Catedral Primada. The Capilla del Rosario, with its zodiac vault, is inside the church and is the element most visitors come to see. The Dominicans returned to the building in 1954 and still occupy it.

The Capilla de Nuestra Señora del Rosario, built in 1649 and rebuilt by the Campuzano Polanco family in 1746, has a barrel vault painted with the twelve zodiac signs around the sun and Olympian gods as the four seasons. It is one of only three astrological vaults known worldwide, alongside those of Salamanca and Río Seco.