El Centro Español de Tampa, Spanish cultural clubhouse in Ybor City, Tampa, Florida.

El Centro Español de Tampa is a red brick building on East 7th Avenue featuring a blend of Mediterranean and Moorish architectural elements highlighted by white stone accents across the facade. The structure contains multiple floors with gathering halls, purpose-built rooms, and detailed interior decorations that reflect its origins as a social gathering place.

The building was constructed in 1912 and became a model for other ethnic mutual aid societies and community organizations that emerged during the period of Spanish immigration. Its establishment reflected a broader movement among immigrant groups to create their own institutions for support and solidarity.

The name Centro Español marks it as the first of Ybor City's Spanish social clubs, founded in 1891 and copied by El Centro Asturiano, El Círculo Cubano and L'Unione Italiana. Members paid dues for classes, dances and health care; the club even ran its own hospital from 1904. The building now houses Jason Fernandez's restaurant Carne, so the former club rooms are seen while dining.

The building stands at 1526–1536 East 7th Avenue in Ybor City, on the south side of the street, and its arched Moorish entrance with cast-iron trim faces 7th Avenue. It now houses the restaurant Carne, so the interior is reached as a dining guest rather than through exhibitions or guided tours. The long east facade with cast-iron balconies is best seen from the sidewalk.

The organization operated its own hospital called Sanatorio del Centro Español, which developed into one of Florida's leading medical facilities in the early 1900s. This hospital was not only a medical center but also a symbol of the Spanish community's ability to build comprehensive services independently.