Casa Rio, Mission Spanish Colonial Revival estate in McGregor Boulevard, Fort Myers, US

Casa Rio is a two-story Spanish Colonial Revival residence on McGregor Boulevard with views of the Caloosahatchee River. The structure features arches, parapets, bell towers, and stucco walls that face the waterfront.

The house was built in 1926 by inventor C.W. Stribley and designed by architects Van Ryn and DeGelleke. It gained National Register status in 1996.

Casa Rio's name and its later history show how a 1926 Mission/Spanish Revival house passed into private hands: since 2001 it has belonged to John A. Carbona, founder of the biotechnology firm AveXis. The house is a private residence, so the architecture is seen from McGregor Boulevard rather than inside.

The interior includes five bedrooms, four and a half bathrooms, seven fireplaces, and original pine wood floors. The riverfront location provides direct access to the Caloosahatchee waterfront with its sea wall protection.

The 2.3-acre NRHP listing covers one contributing building and two contributing structures. The house has been owned since 2001 by John A. Carbona, founder of the biotechnology firm AveXis. Van Ryn and de Gelleke, the architects, worked mostly in Wisconsin, where their 1910 Charles W. Stribley House in Kaukauna is also NRHP-listed.