Our Lady of Guadalupe Church, Catholic church in North Beach, San Francisco, United States

Our Lady of Guadalupe Church is a former Catholic church at 906 Broadway, above the Broadway Tunnel in Russian Hill, San Francisco. Designed by Frank T. Shea and John D. Lofquist in the Mission Revival style, it was one of the first churches in the United States built of reinforced concrete. Its white facade has twin towers topped by gilded crosses, a central rose window with a mosaic figure above, and arched niches holding sculpted figures.

The congregation formed in 1875 from Mexican, Spanish and Portuguese immigrants; their 1880 church was destroyed by the April 1906 earthquake and fire. The present building was consecrated in 1912. Archbishop John R. Quinn ordered its closure in 1992, and in 1993 it was designated city landmark no. 204 after about 5,000 signatures were collected.

The name comes from the Mexican, Spanish and Portuguese immigrants who formed the congregation in 1875. Since 1994 the building has housed St. Mary's Chinese School, and from 2016 the interior served as the 906.World Cultural Center, a co-working and conference space its owner Pavel Cherkashin wanted to bring people together in, as the church had done.

The former church stands at 906 Broadway, above the Broadway Tunnel in Russian Hill, not North Beach. It is no longer an active parish, so there are no masses; the interior now serves as a co-working and event space called 906.World Cultural Center, and the former rectory holds 17 co-living units. Visitors should check event access rather than parish schedules.

The 1888 Hook & Hastings organ, moved here in 1912 from the First Unitarian Church, survives unaltered and is the largest unaltered 19th-century pipe organ in California. The faces of the angels painted on the ceiling frescos were modeled on members of the children's choir.