Charles and Anna Drain House, Historic residence in Drain, Oregon, United States.

The Charles and Anna Drain House is a Queen Anne style house completed in 1895 in Drain, Oregon. Its owners built it from architect George Franklin Barber's Cottage Souvenir No. 2, design number 37, a mail-order plan. The building now houses the Drain school district headquarters.

Charles Douglas Drain, youngest son of town founder Charles Drain, commissioned the house, completed in 1895. The owners chose architect George Franklin Barber's Cottage Souvenir No. 2, design number 37. It was added to the National Register of Historic Places in 1978.

The house takes its name from Charles Douglas Drain, youngest son of town founder Charles Drain, and his wife Anna. Its design came from George Franklin Barber's Cottage Souvenir No. 2 catalogue, plan number 37, a mail-order pattern sold to builders nationwide. The building now houses the Drain school district headquarters.

The house stands on South Main Street in Drain, Oregon, and now serves as the Drain school district headquarters, so the interior is not open to visitors. It can be seen from the street, and the town lies along Interstate 5 between Eugene and Roseburg.

The house was built from architect George Franklin Barber's mail-order plan Cottage Souvenir No. 2, design number 37, chosen by the owners. Barber sold such pattern-book designs by catalogue to clients across the country, so the Drain house is one of many built from the same published drawing.