Botanischer Garten Karlsruhe, Botanical garden and cultural heritage monument in Karlsruhe, Germany.

Botanischer Garten Karlsruhe is a botanical garden in central Karlsruhe that displays plants from Mediterranean, tropical, and arid climatic zones. It combines open-air sections with several greenhouses that protect temperature-sensitive species throughout the year.

The garden's origins trace to Margrave Karl Wilhelm von Baden-Durlach, who laid out a pleasure garden between the palace wings. Around 1800 Karl Friedrich had the grounds remodelled in the English style, and from 1808 a new botanical garden was created west of the palace to plans by Friedrich Weinbrenner. Its wooden plant houses soon decayed, so in the 1850s Grand Duke Friedrich I had them rebuilt to designs by building director Heinrich Hübsch, partly with iron structures; these survive largely today.

The garden is cared for by Staatliche Schlösser und Gärten Baden-Württemberg as a state-owned monument, and an exhibition in the Torbogengebäude explains its history. The plant houses are open daily except Monday, and an admission fee is charged. The garden is not the same as the Botanical Garden of the KIT nearby.

The garden is easy to reach on foot from the city center, as it sits right next to the palace park. Allow at least a couple of hours to walk through the outdoor areas and step into the greenhouses without rushing.

The Camellia House, one of the historic greenhouse structures, was repurposed over time and now holds a collection of cacti and succulents instead of the flowering plants it once sheltered. This shift from camellias to desert plants in the same building is an unusual detail that most visitors walk past without noticing.