Hôtel-Dieu de Marseille, Hospital building in 2nd arrondissement, France.

Hôtel-Dieu de Marseille is a former hospital built from 1753 in pale cream limestone around a courtyard, in the Panier district. Its central block has a round clock in a small arched pavilion at the roofline, above two tiers of tall arches on columns. Félix Blanchet added a storey and extended the left wing in 1860–1866.

Founded in 1593 by merging the Saint-Jacques-de-Galice and Saint-Esprit hospitals, the Hôtel-Dieu was rebuilt from 1753 to plans by Jacques Hardouin-Mansart de Sagonne, with Claude-Henri-Jacques d'Ageville adapting the courtyards and side staircases. Félix Blanchet remodelled it in 1860–1866, adding a storey and clearing the slums around the entrances; Napoleon III inaugurated it on 15 November 1866.

The name Hôtel-Dieu, "house of God", marks a hospital run under the Ancien Régime with exclusively lay staff, unlike other French hospitals of the time. From 1818 its own doctors taught in a secondary school of medicine, and until November 2006 the building trained midwives, anaesthetist nurses, operating-theatre nurses and health managers.

The building is now accessible as a hotel and has been modernized inside while maintaining its historical exterior appearance. Visitors should note that public access may be limited since it functions as a private hospitality business.

The building was designed by Jacques Hardouin-Mansart de Sagonne, grandson of Jules Hardouin-Mansart, who meant it to rival the Hôtel-Dieu of Lille by Pierre de Vigny and of Lyon by Jacques-Germain Soufflot, his fellow members of the Royal Academy of Architecture. Financial difficulties meant only about half of his project was built by 1788.