Saint Sargis Church, Tbilisi, Armenian church building in Tbilisi, Georgia.

Saint Sargis Church was a cross-domed Armenian church on the right bank of the Mtkvari in the Abanotubani district of Old Tbilisi. A bilingual Georgian and Armenian marble inscription dated 1883 was set into its east wall. The church was demolished in the 1930s; several walls remain, incorporated into a later residential room.

The church was founded in 1737 and served the Armenian community of Tbilisi as a center of worship for several centuries. It was demolished during the Soviet period in the 1930s when many religious buildings in the city were removed.

The church served as a gathering place for the Armenian community in Tbilisi and reflected their significant presence in the city's religious life. Armenian families marked important celebrations and rituals here for generations.

The location where the church stood is in central Tbilisi and was accessible on foot just as other religious sites in the city remain today. Visitors interested in learning more about Armenian churches can find other surviving Armenian places of worship still standing in the city.

A marble slab set into the church's east wall carried a bilingual Georgian and Armenian inscription dated 1883. In May 1936, a house 20–25 metres away collapsed, killing an entire family; a secret police letter then proposed using that accident to close the church quietly.