San Francesco ad Alto, Franciscan church in Ancona, Italy.

San Francesco ad Alto is a former Franciscan church on Colle Astagno in Ancona, now deconsecrated and used as a military hospital since 1863. Its large hall was divided into floors and the bell tower was truncated above the bell chamber. The interior was reorganized at the end of the 15th century into three naves separated by two rows of columns, with an apse and sacristy added.

Saint Francis of Assisi chose this location during his visit to Ancona in 1219 to establish a church and the first Franciscan convent. Over the centuries the building underwent multiple transformations, eventually converted into a military hospital in 1863 following Italian unification.

The name "ad Alto" is said to come from words Saint Francis spoke on the port quays, pointing to Colle Astagno as the site for Ancona's first Franciscan church and convent. The church is no longer consecrated: the last religious service was held on 2 May 1863, before it became a military hospital.

The former church is no longer open for worship: the last religious service was held on 2 May 1863, after which the building was taken over by the state and turned into a military hospital, with the great hall divided into floors. Its furnishings and paintings were dispersed across Ancona, so the Titian and Crivelli panels are now seen at the Pinacoteca civica Francesco Podesti.

The church's wooden high altar was moved after World War II to San Francesco alle Scale, and its bells went to Santi Cosma e Damiano, whose bell tower by Godeardo Bonarelli is an exact replica of the demolished one here. The Titian altarpiece of 1520, his first signed work, is now in the Pinacoteca Podesti.