San Domenico, Baroque church in Ancona, Italy

San Domenico is a Baroque church in Ancona featuring prominent columns, ornate altars, and detailed stone carvings throughout its interior. The structure displays characteristic elements of the Baroque style with elaborate decorative details in every section.

Carlo Marchionni designed the present church in 1763 and the first stone was laid in 1771, replacing a 13th-century church that stood further left. The facade was still unfinished when French occupation turned the building into a barracks in 1798; the upper order was never completed. It reopened for worship in 1816 under the Restoration, and after the 1930 earthquake the upper facade was altered with reinforced concrete and brickwork.

The third chapel on the left is a votive chapel for the fallen of the First World War, rebuilt in 1946 to a design by Eusebio Petetti using repen and bardiglio marble; it holds a marble Pietà by Sanzio Blasi (1895–1972). Above the cornice, four musician angels by Gioacchino Varlè stand as if leaning on it.

The church stands at the top of a staircase on one of the short sides of Piazza del Papa, so the approach is by steps rather than a level street. The facade faces the square; the brick bell tower rises to its right and is partly hidden by it. The upper part of the facade was rebuilt in reinforced concrete and brick after the 1930 earthquake.

The Titian Crucifixion of 1558, painted for the earlier San Domenico, hung much lower in the church than its present position; it is now kept at the Pinacoteca civica Francesco Podesti so it can be seen more easily. The church also keeps the Guercino Annunciation in the first chapel on the left.