Sant'Antonio Abate, Baroque church building in Rieti, Italy

Sant'Antonio Abate is a church in Rieti whose brick facade rises above a base of large Roman wall blocks on Via Tancredi. The central nave is flanked by three chapels per side and covered by a lunetted barrel vault ending in a semicircular apse. Jacopo Barozzi da Vignola designed it in 1570 for the Compagnia del Sacramento; the curved portal moulding and stucco cornice are attributed to Onorio Longhi.

In July 1570, the Sacramento Company commissioned architect Jacopo Barozzi da Vignola to design a new church to replace a small chapel at the Sant'Antonio Abate hospital. This project was part of broader religious building efforts in Rieti during the Renaissance period.

The church hosted the annual blessing of animals for the feast of Saint Anthony, a rite tied to the hospital complex that served the city until 1972. Today the blessing is recalled each year by a parade of horses with ribbons in their manes through Rieti's streets, since the church itself stands closed.

The building has been closed to the public since 2003 due to structural damage sustained during the 1997 earthquake and ongoing restoration work. Visitors should note that access is not currently possible, though the exterior can be viewed from the surrounding area.

The 2019 restoration of the main wooden door turned up a coin from the late 1600s hidden inside it. The find came during work funded by the Lazio region to make the windows and doors functional again, and it is one of the few objects tied to the building's long construction history.