Santa Maria Domenica Mazzarello, Catholic parish church in Don Bosco, Rome, Italy

Santa Maria Domenica Mazzarello is a modern church building in eastern Rome designed with contemporary architectural features and a main hall that accommodates roughly three hundred worshippers. The structure reflects a functional approach to religious space with clean lines and straightforward design elements.

The parish was established on 15 March 1982 by vicar cardinal Ugo Poletti, and the church was completed and consecrated by cardinal Camillo Ruini on 1 March 1997. Pope John Paul II visited it on 14 December 1997. Assigned to the clergy of Lodi in 2000, it returned to Roman clergy care on 1 September 2012, and became a titular church on 21 February 2001.

The church is named after Maria Domenica Mazzarello (1837–1881), the Italian founder of the Salesian Sisters, the Daughters of Mary Help of Christians. A large modern canvas at the back of the hall shows the titular saint. The parish was entrusted to the secular clergy of the Diocese of Lodi in 2000, then returned to Roman clergy on 1 September 2012.

The church is located on Piazza Salvatore Galgano in eastern Rome and is primarily accessible to visitors during mass times and religious celebrations. It helps to check opening times before visiting to find a suitable moment to enter.

The church became a titular church on 21 February 2001. Its first cardinal-priest was Venezuelan Ignacio Antonio Velasco García, followed by Australian George Pell in 2003 and South African Stephen Brislin in 2023. The title is held by a cardinal who is not resident in the parish.