Palazzo Alberini, Renaissance palazzo in Via del Banco di Santo Spirito, Rome, Italy.

Palazzo Alberini is a three-story palace on Via del Banco di Santo Spirito with a ground floor featuring smooth rustication and a noble floor with continuous cornices. The upper level displays rectangular windows arranged in a balanced, ordered fashion typical of Renaissance design.

The palace was built between 1515 and 1521 for the Alberini family, combining design ideas from both Raffaello and Giulio Romano. It reflects architectural influences from Bramante's earlier works and helped shape Renaissance style in the city.

The building mixes shops and workspaces on the ground level with living quarters above, showing how Renaissance Rome organized social and economic life. This arrangement was common for wealthy families who lived and worked in the same place.

The original Renaissance facade faces the narrow Vicolo del Curato, perpendicular to Via del Banco di Santo Spirito, where the 19th-century facade stands at number 12. Visitors should look along the side alley to see the earlier design, since the main street front was rebuilt in the 1800s.

The design borrows heavily from Florentine palace patterns and closely follows the style of Bramante's Palazzo Caprini. This mix of Florentine and Roman styles was unusual for Rome and made the building a notable example of regional architectural traditions coming together.