Palazzo Pica Alfieri, Baroque palace in L'Aquila, Italy.

Palazzo Pica Alfieri is a Baroque palace in L'Aquila with a three-part facade, a columned loggia, and two entrance doors. The building has a rectangular floor plan organized around a large inner courtyard.

The palace stands on the site of the Renaissance Palazzo del Conte di Montorio, where Queen Giovanna d'Aragona stayed in 1493. In 1685 Ludovico Alfieri bought the building from Maffeo Barberini for 1,700 ducats. After the 1703 earthquake it was rebuilt to designs by Francesco Fontana, and in 1785 the marriage of Eusebia Alfieri to Giannantonio Pica gave it the name Pica-Alfieri.

Inside you can find an art gallery displaying works by Italian painters arranged throughout the rooms and inner courtyard. The collection reflects the region's artistic traditions that developed over time.

The palace stands on Piazza Santa Margherita along Via Roma, the decumanus of L'Aquila's Angevin street grid. Its main facade faces the Palazzo della Congregazione dei Nobili, with the church of Santa Margherita on one side and the Palazzo Margherita, now the town hall, on the other. Reconstruction after the 2009 earthquake began on 15 September 2014 and the palace reopened to the public on 29 September 2018.

The palace stands on the site of the Palazzo del Conte di Montorio, a Renaissance building where Queen Giovanna d'Aragona stayed in 1493. The property later passed to Pompeo Colonna and became the official residence of the treasurer of Abruzzo Ultra, hosting Andrea Ardinghelli and Margherita Strozzi.