Palazzo Guadagni dell'Opera, Renaissance palace in Piazza del Duomo, Florence, Italy.

Palazzo Guadagni dell'Opera is a stone building on Piazza del Duomo featuring ornate windows, a decorated entrance portal, and a curved facade that follows the square's perimeter. The structure displays carefully crafted details that demonstrate the skill of craftsmen from that era.

The building stands on land once occupied by the Bischeri family homes, which were sold to Bartolomeo di Rosso Buondelmonti in 1484. Later, significant modifications were made to the structure, particularly by architect Gherardo Silvani during the Renaissance.

The name "Guadagni dell'Opera" distinguishes this branch of the family from the Guadagni of Santo Spirito, because the palace stands next to the houses of the Opera del Duomo. The 1723 inventory lists paintings by Ghirlandaio, Perugino, Titian, Tintoretto, Caravaggio and Michelangelo, alongside contemporary Florentine painters such as Anton Domenico Gabbiani and Pier Dandini.

The palazzo now serves as the headquarters of the Regional Council of Tuscany following a comprehensive restoration. Visitors should know that access times and conditions depend on official schedules and regulations.

The seven-axis facade curves to follow the perimeter of Piazza del Duomo, probably adapting to earlier buildings on the site. Silvani's surviving autograph drawing shows pilasters between the windows that were never built, perhaps because they made the facade look too much like a grid with the string courses.