San Serafino da Montegranaro, Baroque church in Ascoli Piceno, Italy.

San Serafino da Montegranaro is a single-nave church in the Borgo Solestà district of Ascoli Piceno, rebuilt from 1771 after the saint's canonization. An arcaded portico projects in front of the facade, whose only ornament is a stucco oval relief of the titular saint; the 16th-century portal architrave reads "PER PARVA AQUIRUNTUR MAGNA". The medieval bell tower survives beside the left apse, and the presbytery walls carry Augusto Mussini's fresco cycle of 1903–1915.

The first church, Santa Maria in Solestano, was founded in the 8th century with a Benedictine monastery under Bishop Iustolfo. The Minor Observants installed Ascoli's first printing press here, producing the Cronaca di Sant'Isidoro in 1477. The Capuchins took over in 1569, and Serafino da Montegranaro lived in the convent from 1590 until his death on 12 October 1604. After his canonization in 1767, the medieval church was replaced by the present building from 1771.

The high altar displays detailed artwork depicting scenes from Saint Serafino's life, showing how religious devotion shaped the decoration of this space. These artworks remain central to how people experience the church today.

The church is located in central Ascoli Piceno and is accessed through the main decorated facade. Regular services take place here, so checking opening times in advance helps you visit comfortably and explore the interior without interruption.

The bell tower beside the left apse is the only surviving element of the medieval church of Santa Maria in Solestano, which stood here before the 1771 rebuilding. The rest of that older structure was replaced after the canonisation of Saint Serafino in 1767.