Desire Plantation House, Historic tobacco plantation in Vacherie, United States.

Desire Plantation House, also called Alcidesire, is a Perique tobacco plantation established around 1835 in Vacherie, St. James Parish, Louisiana. The plantation house stands along Louisiana Highway 644 and was listed on the National Register of Historic Places in 1986.

The house was constructed in 1835 and later recognized on the National Register of Historic Places in 1986. This designation acknowledged its importance to agricultural development and its value as a surviving example of plantation architecture.

The name Alcidesire combines Alcidie LeBlanc, born in 1854 to Desire LeBlanc and Aglaé Bourgeois, with her father's name; she married Louis S. Webre in April 1885. The property is a Perique tobacco plantation, a crop cured under pressure in St. James Parish.

The property is privately owned and not freely accessible to the public for casual visits. Inquiries about research visits or viewing should be directed to local historical preservation organizations.

The plantation is also known as Alcidesire, a name combining Alcidie LeBlanc and her husband Louis S. Webre, married in April 1885. Alcidie was the daughter of Desire LeBlanc, born in 1831 and married to Aglaé Bourgeois in 1854, the year Alcidie was born. The couple's son Joseph M. Webre was born in 1888.