General German Protestant Orphans Home, Historic orphanage building in Indianapolis, Indiana.

The General German Protestant Orphans Home, also called Pleasant Run Children's Home, is a 2+1⁄2-story brick institutional building on a limestone block foundation. Architect Diedrich A. Bohlen gave it eclectic German vernacular detailing and varying roof forms.

The General German Protestant Orphans Home was designed by architect Diedrich A. Bohlen (1827–1890) and built in 1871–1872. It was listed on the National Register of Historic Places in 1984.

The building reflects German architectural traditions through its brick construction and design elements, showing how German-speaking families shaped the neighborhood during the 1800s. These features remain visible to visitors walking through the area today.

The orphanage building stands in Indianapolis, Indiana, and is not open to the public, so there are no tours or visiting hours to plan around. It can be viewed from the street as a brick institutional structure on a limestone block foundation. Its National Register listing dates from 1984.

The building was added to the National Register of Historic Places in 1984, acknowledging its contribution to local architectural and social history. This recognition highlights its importance as a record of the past.