Downtown Wenatchee Historic District, National Register Historic District in Wenatchee, United States.

Downtown Wenatchee Historic District covers 34 acres (14 ha) of Wenatchee's central business district and holds 57 contributing and 32 noncontributing properties, built between 1902 and 1955. Its commercial, mixed-use and warehouse buildings line Columbia Street, Wenatchee Avenue, Mission Street and Orondo Avenue; the Old Stone Warehouse (c. 1906) and the 1929 Cascadian Hotel are among them.

The district grew between 1902 and 1955 as Wenatchee became a trading and storage center for the region's fruit industry. Key buildings like the Old Stone Warehouse from 1906 and the Dow Fruit Company facility from 1920 reflect this period of expansion.

The district's fruit-industry past survives in names still on the facades: the Dow Fruit Company building at 101 South Columbia Street (c. 1920), the Northwestern Fruit Exchange at 131 South Wenatchee Avenue (1913), and the Fruit Growers Service Building at 10 South Columbia Street (c. 1926). The 1922 Public Farmers Market building at 9 North Wenatchee Avenue recalls the produce trade that filled these blocks.

Information signs are posted throughout the neighborhood explaining the history of individual buildings and their uses. Parking is available near the main structures, and the area is easy to explore on foot.

The Old Post Office Building and its annex on South Mission Street were listed individually on the National Register in 1977, three decades before the wider district followed in 2008. The 1938 post office now houses the Wenatchee Valley Museum & Cultural Center, while the 1918 annex stands next to it.