Museo Regional de Atacama, Regional museum in Copiapó, Chile.

The Museo Regional de Atacama occupies the Casa de los Hermanos Matta, a neoclassical house built in the mid-19th century and declared a National Monument in 1979. Its walls combine Guayaquil cane and timber framing with Oregon pine brought from North America, resting on an uncut stone base. Four rooms cover 12,000 years of human occupation, from the archaic period to the 19th century.

The museum opened on 8 December 1973 in the Casa de los Intendentes on Calle Atacama 630, showing archaeological, mineralogical and historical collections from the Universidad Técnica del Estado, the Escuela Normal Rómulo J. Peña and the Liceo de Hombres de Copiapó. It joined DIBAM by decree of 19 April 1974 and moved to Villa El Sol in 1978. In 1982 it reopened in the Casa de los Hermanos Matta, a neoclassical house declared a National Monument in 1979.

The exhibition features everyday objects from past inhabitants of the region, including pottery and tools that reveal how people adapted to life in the desert. These items show the connection between the communities and their harsh environment.

The museum occupies the Casa de los Hermanos Matta, a neoclassical house on Calle Atacama in central Copiapó, declared a National Monument in 1979. The February 2010 and June 2025 earthquakes left structural damage and losses to its coverings, so check locally which rooms are open before visiting. The building is reached on foot from the city centre; its timber, cane and mud walls and stone foundation are visible in the fabric of the house.

The collection holds the Fénix 2 capsule that lifted the 33 trapped miners of the San José mine to the surface in 2010, along with the handwritten note "Estamos bien en el refugio los 33" by miner José Ojeda. Both entered the museum's collection under director Guillermo Cortés Lutz, who has led the institution since 2009.