Museo Regional de Antofagasta, Regional museum in Historic District, Antofagasta, Chile.

The Museo Regional de Antofagasta occupies the former Antofagasta customs house, a two-storey timber building with a U-shaped plan, an open front corridor and a balcony running around the whole upper floor. Its twelve exhibition rooms and an auditorium hold about 10,000 pieces: pre-Hispanic coastal archaeological objects, historical documents and geological minerals. The building was made in Valparaíso by Wetmare & Cía. in 1867 and assembled in Mejillones in 1869.

The building was constructed in 1867 as the city's customs house and served as an administrative building for years. It was declared a protected cultural monument in 1972 and converted to a museum in 1984.

The museum displays objects from before Spanish settlement and items connected to mining in the region. These collections tell the story of how people lived and worked in northern Chile across different periods.

The museum sits in the downtown area and is easy to reach on foot, with clear signage and open entrance areas for visitors. Opening hours differ on weekdays and weekends, so check the schedule before visiting.

The customs building was prefabricated in Valparaíso by Wetmare & Cía. in 1867, shipped by sea and reassembled in Mejillones in September 1869; in 1888 it was dismantled again and moved to Antofagasta after the Bolivian customs house burned in 1885. A watchtower stood on top until it was removed in 1940.